In gout, high uric acid in serum leads to deposition of uric acid crystals in which sites?

In gout, high uric acid in serum leads to deposition of uric acid crystals in which sites?

• A. Deposition of uric acid crystals in joints, soft tissues, and kidneys
• B. Activation of T cells
• C. Decreased uric acid production
• D. Calcium deposition in bones

Answer: (A)

High serum uric acid causes monosodium urate crystals to precipitate in joints, soft tissues, and kidneys. When crystals settle in joints, they trigger a strong inflammatory response, leading to the sharp, swollen pain of gouty arthritis. In soft tissues, crystal deposition forms tophi, which are nodules that can develop over time. In the kidneys, crystals can lodge and form stones, potentially affecting kidney function. This is why deposition in joints, soft tissues, and kidneys is the correct description. The other options don’t describe where urate crystals deposit: T cell activation is part of the inflammatory process rather than a deposition site; decreased uric acid production would reduce crystal formation; and calcium deposition in bones isn’t related to gout.

High serum uric acid causes monosodium urate crystals to precipitate in joints, soft tissues, and kidneys. When crystals settle in joints, they trigger a strong inflammatory response, leading to the sharp, swollen pain of gouty arthritis. In soft tissues, crystal deposition forms tophi, which are nodules that can develop over time. In the kidneys, crystals can lodge and form stones, potentially affecting kidney function. This is why deposition in joints, soft tissues, and kidneys is the correct description. The other options don’t describe where urate crystals deposit: T cell activation is part of the inflammatory process rather than a deposition site; decreased uric acid production would reduce crystal formation; and calcium deposition in bones isn’t related to gout.