Uric acid crystals deposit in which tissues in gout?

Uric acid crystals deposit in which tissues in gout?

• A. Joints
• B. Soft tissues
• C. Kidneys
• D. Brain

Answer: (C)

Uric acid crystals primarily accumulate in the joints, where they provoke the acute inflammatory arthritis characteristic of gout. These crystals settle in the synovial fluid and around articular cartilage, leading to sudden, severe pain, redness, and swelling. They can also form in soft tissues as tophi around joints, and urate stones can develop in the kidneys as a complication, but the hallmark tissue where crystal deposition first and most notably occurs is the joint. Brain is not a typical site for urate deposition in gout.

Uric acid crystals primarily accumulate in the joints, where they provoke the acute inflammatory arthritis characteristic of gout. These crystals settle in the synovial fluid and around articular cartilage, leading to sudden, severe pain, redness, and swelling. They can also form in soft tissues as tophi around joints, and urate stones can develop in the kidneys as a complication, but the hallmark tissue where crystal deposition first and most notably occurs is the joint. Brain is not a typical site for urate deposition in gout.