Which tissue is NOT a typical site for uric acid crystal deposition?

Which tissue is NOT a typical site for uric acid crystal deposition?

• A. Joints
• B. Kidneys
• C. Liver
• D. Brain

Answer: (C)

Urate crystals form where urate concentration is high enough to exceed solubility, which is most characteristic in joints (leading to gout) and in the kidneys (uric acid nephrolithiasis or nephropathy). The joint environment is cooler and the synovial fluid can concentrate urate, while the kidneys concentrate and excrete urate, exposing renal tubules to high levels. Brain and liver沒有 typical sites for crystal deposition because the conditions there don’t favor urate crystallization—the brain is protected by barriers and the liver handles purine metabolism without forming crystals in tissues. Therefore, the liver is not a typical site for uric acid crystal deposition.

Urate crystals form where urate concentration is high enough to exceed solubility, which is most characteristic in joints (leading to gout) and in the kidneys (uric acid nephrolithiasis or nephropathy). The joint environment is cooler and the synovial fluid can concentrate urate, while the kidneys concentrate and excrete urate, exposing renal tubules to high levels. Brain and liver沒有 typical sites for crystal deposition because the conditions there don’t favor urate crystallization—the brain is protected by barriers and the liver handles purine metabolism without forming crystals in tissues. Therefore, the liver is not a typical site for uric acid crystal deposition.